Pandemic Vaccine Thoughts Continued

---------- Forwarded message --------- From: John Ames Birch <Birch403@outlook.com> Date: Thu., Jun. 3, 2021, 6:24 p.m. Subject: Fwd: Pandemic Vaccine Thoughts Continued (Opinion) To: justin.trudeau@parl.gc.ca <justin.trudeau@parl.gc.ca>, Chrystia.Freeland@parl.gc.ca <Chrystia.Freeland@parl.gc.ca>, dujarric@un.org <dujarric@un.org>, Rota, Anthony - Riding 1 <Anthony.Rota.C1@parl.gc.ca>, antonio.ferrari@un.org <antonio.ferrari@un.org>, ANKRA-Consular@international.gc.ca <ANKRA-Consular@international.gc.ca>, amesbirch403@gmail.com <amesbirch403@gmail.com>, actso@naacpnet.org <actso@naacpnet.org>, aclupreferences <aclupreferences@aclu.org>, ASKUS <ASKUS@novascotia.ca>, accredit@gov.ru <accredit@gov.ru>, america@aljazeera.net <america@aljazeera.net>, assistance@liberal.ca <assistance@liberal.ca>, Minister, AGRI AGRI:EX <AGR.Minister@gov.bc.ca>, Blanchet, Yves-François - Député <Yves-Francois.Blanchet@parl.gc.ca>, Bennett, Carolyn - M.P. <carolyn.bennett@parl.gc.ca>, bgantz@knesset.gov.il <bgantz@knesset.gov.il>, beril.aktas@hurriyet.com.tr <beril.aktas@hurriyet.com.tr>, ctvottawa@ctv.ca <ctvottawa@ctv.ca>, Qualtrough, Carla - 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Hey everyone, Further to the below emails I sent last year to develop a vaccine I have been thinking about the variants. I was thinking that we need to create a vaccine that will deal with all variants at once. I was thinking that we should create an open ended vaccine. This vaccine when it encounters a variant would absorb its genetic information and include it within the vaccine Antibody genome. From here the vaccine antibodies would then replicate the new variant antibody without the need for a booster shot. As such if our scientific community can review this option to determine feasibility it would be greatly appreciated.

Stay safe, stay sanitized and stay supportive, John Ames Birch @johneames2 Get Outlook for Android From: J Birch <Birch403@outlook.com> Sent: Tuesday, May 5, 2020, 11:00 PM To: dujarric@un.org; justin.trudeau@parl.gc.ca; GlobalOttawa@globalnews.ca; news@skynews.com; tips@GlobalTVBC.com; newsonline@ctv.ca; contact.nbcnews@nbcuni.com; she@emro.who.int; eurohealthycities@who.int; ogawah@wpro.who.int; Secretary@HHS.gov; Info@hc-sc.gc.ca; Chrystia.Freeland@parl.gc.ca; media@gatesfoundation.org Subject: Re: Pandemic Vaccine Thoughts Continued (Opinion) Hey Everyone, I was having a thought about the pathogen and the lungs and it might travel through the alveoli via the blood oxygen transfer. Perhaps the transfer creates a two way connection from the blood to the lungs by binding to the carbon dioxide we exhale. If there is a way to stop the process or use the carbon dioxide to nullify this reaction or the virus it might help protect our lungs. I'm not sure if there is a way to protect the oxygen transfer process and limit anything other then oxygen particles from entering the lungs, similar to a mask for your lungs for viruses. This might help us to reduce viral spread in flu season as well by limiting the viruses pathways from the blood to the outside world and vice versa. Focusing on protecting the body as well as the cells. Stay Safe, Stay Sanitized and Stay Supportive, John Ames Birch @johneames2 From: J Birch <Birch403@outlook.com> Sent: May 5, 2020 2:04 PM To: dujarric@un.org <dujarric@un.org>; justin.trudeau@parl.gc.ca <justin.trudeau@parl.gc.ca>; GlobalOttawa@globalnews.ca <GlobalOttawa@globalnews.ca>; news@skynews.com <news@skynews.com>; tips@GlobalTVBC.com <tips@GlobalTVBC.com>; newsonline@ctv.ca <newsonline@ctv.ca>; contact.nbcnews@nbcuni.com <contact.nbcnews@nbcuni.com>; she@emro.who.int <she@emro.who.int>; eurohealthycities@who.int <eurohealthycities@who.int>; ogawah@wpro.who.int <ogawah@wpro.who.int>; Secretary@HHS.gov <Secretary@HHS.gov>; Info@hc-sc.gc.ca <Info@hc-sc.gc.ca>; Chrystia.Freeland@parl.gc.ca <Chrystia.Freeland@parl.gc.ca>; media@gatesfoundation.org <media@gatesfoundation.org> Subject: Re: Pandemic Vaccine Thoughts Continued (Opinion) Hey Everyone, I was reading a story about a new mutation they found that has created a new version of the virus. This version is even more virulent and therefore spreads faster then earlier version. They have also discovered that this version shows more virus particles in patients with this strain, this means these patients have more of the virus in their bodies. If this report is accurate then it means the mutation might have occurred in the proteins or replication standard of the virus to allow it to reproduce more readily and spread faster and quicker. In my humble opinion we should focus on finding ways to mitigate the viruses ability to replicate. If we can reduce the number of viral particles within the patient hopefully we can reduce the contagion factor of that strain. Perhaps if there is a drug that focuses on replication we can use it to help reduce the spread of this strain and coupled with vaccine efforts we should be able to cure both strains and amend the vaccine when needed for booster shots. This was a thought I was having and wanted to share. Stay Safe, Stay Sanitized and Stay Supportive, John Ames Birch @johneames2 From: J Birch <Birch403@outlook.com> Sent: April 23, 2020 8:06 PM To: dujarric@un.org <dujarric@un.org>; justin.trudeau@parl.gc.ca <justin.trudeau@parl.gc.ca>; GlobalOttawa@globalnews.ca <GlobalOttawa@globalnews.ca>; news@skynews.com <news@skynews.com>; tips@GlobalTVBC.com <tips@GlobalTVBC.com>; newsonline@ctv.ca <newsonline@ctv.ca>; contact.nbcnews@nbcuni.com <contact.nbcnews@nbcuni.com>; she@emro.who.int <she@emro.who.int>; eurohealthycities@who.int <eurohealthycities@who.int>; ogawah@wpro.who.int <ogawah@wpro.who.int>; Secretary@HHS.gov <Secretary@HHS.gov>; Info@hc-sc.gc.ca <Info@hc-sc.gc.ca>; Chrystia.Freeland@parl.gc.ca <Chrystia.Freeland@parl.gc.ca>; media@gatesfoundation.org <media@gatesfoundation.org> Subject: Re: Pandemic Vaccine Thoughts Continued (Opinion) Hey everyone, I am writing you today with regards to the virus and the fact many patients are developing blood clots in mysterious areas of the body. I was brainstorming a few ideas as to why this might be occuring and wanted to share my thoughts in the hopes of resolving this symptom or at least understanding it. I was wondering if perhaps this virus attacks the inner workings of the cell and causes it to activate the protein responsible for blood coagulation. Also I was wondering if there is a way that we can determine if the virus is somehow causing a magnetic change that is attracting the iron in the cells and causing blood clots or if even the virus is attracted to itself. Additionally, I understand that the application of blood thinners is dangerous, as it can cause a person to bleed uncontrollably. I was thinking that they have used sonic waves to breakup the blood clots in patients in the past and perhaps we can use a similar method to help the patients in the hospital. Perhaps even vibrating beds to help breakup clots as they form in the patients body or even directed sonic waves to unclog existing blockages might be something to consider. These were just a few of the ideas that I was having and wanted to share. Stay Safe, Stay Sanitized and Stay Supportive, John Ames Birch @johneames2 From: J Birch <Birch403@outlook.com> Sent: April 19, 2020 9:13 PM To: dujarric@un.org <dujarric@un.org>; justin.trudeau@parl.gc.ca <justin.trudeau@parl.gc.ca>; GlobalOttawa@globalnews.ca <GlobalOttawa@globalnews.ca>; news@skynews.com <news@skynews.com>; tips@GlobalTVBC.com <tips@GlobalTVBC.com>; newsonline@ctv.ca <newsonline@ctv.ca>; contact.nbcnews@nbcuni.com <contact.nbcnews@nbcuni.com>; she@emro.who.int <she@emro.who.int>; eurohealthycities@who.int <eurohealthycities@who.int>; ogawah@wpro.who.int <ogawah@wpro.who.int>; Secretary@HHS.gov <Secretary@HHS.gov>; Info@hc-sc.gc.ca <Info@hc-sc.gc.ca>; Chrystia.Freeland@parl.gc.ca <Chrystia.Freeland@parl.gc.ca>; media@gatesfoundation.org <media@gatesfoundation.org>; J Birch <BIRCH403@OUTLOOK.COM> Subject: Re: Pandemic Vaccine Thoughts Continued (Opinion) Hey Everyone, I was having an additional thought in relation to the Pandemic, I was looking at reasons for why the pathogen seems to affect people differently and how the symptoms can vary to such a degree. I was wondering if it was due to one or two possibilities, perhaps given the polar caps melting I was wondering if this is an older form of a virus that is less advanced and unstable to our biology which is why the range of effects is so broad. Alternatively, I was thinking perhaps its a mutation in the early gene sequence that causes it to mutate in a variety of ways based on the body chemistry and DNA of the affected person. This got me thinking that perhaps we can somehow use this to our advantage. If we can someone alter the early gene expression we might be able to direct the mutation and the symptoms people get to temper the pathogen in a sense. This will allow us to direct the virus to more of a benign early gene expression and hopefully save more lives. This was a thought I was having and wanted to share. Stay Safe, Stay Sanitized and Stay Supportive, John Ames Birch @johneames2 From: J Birch <Birch403@outlook.com> Sent: April 17, 2020 4:28 AM To: dujarric@un.org <dujarric@un.org>; justin.trudeau@parl.gc.ca <justin.trudeau@parl.gc.ca>; GlobalOttawa@globalnews.ca <GlobalOttawa@globalnews.ca>; news@skynews.com <news@skynews.com>; tips@GlobalTVBC.com <tips@GlobalTVBC.com>; newsonline@ctv.ca <newsonline@ctv.ca>; contact.nbcnews@nbcuni.com <contact.nbcnews@nbcuni.com>; she@emro.who.int <she@emro.who.int>; eurohealthycities@who.int <eurohealthycities@who.int>; ogawah@wpro.who.int <ogawah@wpro.who.int>; Secretary@HHS.gov <Secretary@HHS.gov>; Info@hc-sc.gc.ca <Info@hc-sc.gc.ca>; Chrystia.Freeland@parl.gc.ca <Chrystia.Freeland@parl.gc.ca>; birch403@outlook.com <Birch403@outlook.com> Subject: Re: Pandemic Vaccine Thoughts Continued (Opinion) Hey Everyone, One final thought I was having for today was in relation to late genes vs early genes. I was wondering if there would be a way to block the early genes in some fashion to prevent protein synthesis and the replication of progeny mRNA. I am wondering if there is a way to provide an immunity to the early stage genes of the virus. I read that they are not usually inhibited by agents that block protein synthesis but I was wondering if there was an alternate way to block the early gene expression of the virus. This was just another quick thought I had and wanted to share to see if it can be of any help to narrow our focus for a vaccine. Stay Safe, Stay Sanitized and Stay Supportive, John Ames Birch @johneames2 From: J Birch <Birch403@outlook.com> Sent: April 16, 2020 8:41 PM To: dujarric@un.org <dujarric@un.org>; justin.trudeau@parl.gc.ca <justin.trudeau@parl.gc.ca>; GlobalOttawa@globalnews.ca <GlobalOttawa@globalnews.ca>; news@skynews.com <news@skynews.com>; tips@GlobalTVBC.com <tips@GlobalTVBC.com>; newsonline@ctv.ca <newsonline@ctv.ca>; contact.nbcnews@nbcuni.com <contact.nbcnews@nbcuni.com>; she@emro.who.int <she@emro.who.int>; eurohealthycities@who.int <eurohealthycities@who.int>; ogawah@wpro.who.int <ogawah@wpro.who.int>; Secretary@HHS.gov <Secretary@HHS.gov>; Info@hc-sc.gc.ca <Info@hc-sc.gc.ca>; Chrystia.Freeland@parl.gc.ca <Chrystia.Freeland@parl.gc.ca> Subject: Re: Pandemic Vaccine Thoughts Continued (Opinion) Hey everyone, I was thinking about how the virus attacks some individuals more aggressively than others. For some they get a few cold like symptoms and some require hospitalization and I was wondering if we can chart the differences between the individual to see if we can figure out why. Perhaps we can review the following to determine if there are any correlations between virus effects and the person. Can we review:

• Genetic similarities between unaffected individuals

  • Genetic or familial markers shared between those less effected.

  • Does blood type factor into the severity of cases?

  • What about geographic location, do a number of benign cases group together in a specific country or city?

  • Does lifestyle or diet factor in? Vegan / meat / vegetarian?

  • Do people with bronchitis or asthma get the virus as regularly or does reduced lung capacity help or hinder?

  • People who drink usually have a weaker immune response, can we determine if this is a factor we need to worry about and quarantine those who drink until after a vaccine is reached? same with smokers?

  • How many mutated strains have we determined exist? and do different strains cause different reactions on the body?

  • For those less effected can we grab blood samples and cross reference our finding to see if there is an existing antibody or difference in genome sequence.

  • Are the people who are less affected taking any existing medications.

    • If they are taking medications are there similar results on different medications or common ingredients between all medicines that we can use as a starting point for a vaccine?

  • Does BMI play a role in strength or weakness of the virus effects?

  • Is the pathogen effected by the amount of virons the person is exposed to? if they catch it from a surface where most of the virus has already died does that change the severity of the symptoms? or does direct, person to person transmission cause more effects on the body?

  • At times the virus can have different effects on the body and I am wondering if there is any correlation between symptoms and person or symptoms and exposure.

These were a few questions I was having and wanted to share to see if answering some of these questions can help us craft a better and quicker vaccine. Stay Safe, Stay Sanitized and Stay Supportive, John Ames Birch @johneames2 From: J Birch <Birch403@outlook.com> Sent: April 13, 2020 10:35 PM To: dujarric@un.org <dujarric@un.org>; justin.trudeau@parl.gc.ca <justin.trudeau@parl.gc.ca>; GlobalOttawa@globalnews.ca <GlobalOttawa@globalnews.ca>; news@skynews.com <news@skynews.com>; tips@GlobalTVBC.com <tips@GlobalTVBC.com>; newsonline@ctv.ca <newsonline@ctv.ca>; contact.nbcnews@nbcuni.com <contact.nbcnews@nbcuni.com>; she@emro.who.int <she@emro.who.int>; eurohealthycities@who.int <eurohealthycities@who.int>; ogawah@wpro.who.int <ogawah@wpro.who.int>; Secretary@HHS.gov <Secretary@HHS.gov>; Info@hc-sc.gc.ca <Info@hc-sc.gc.ca>; Chrystia.Freeland@parl.gc.ca <Chrystia.Freeland@parl.gc.ca> Subject: Re: Pandemic Vaccine Thoughts Continued (Opinion) Hey Everyone, I was researching alternate options for combatting this virus and have a few different ideas that might help. I was wondering if there is a way to create an immune response within the cell itself, have the cell recognize the pathogenic structure of the virus and once detected the cell would initiate a cellular immune response on its own. Additionally I was wondering if we can introduce an antiviral specifically targeted to the genome of this virus. Using chemical, electrical or radioactive component that is safe for the human body but hazardous to the virus. Similar to chemotherapy but on a cellular level. Finally, a new approach I was wondering if we can create pathogenic antibodies that would be designed after the virulent capabilities and replication standard of the virus we are facing. They would be cells designed to replicate at the same speed and seek out the virus virons like a magnet and encapsulate them in a bilayer materials that would be locked against replication, cell budding or cell lysis. These particles can then be extracted from the body through regular ways and thereby prevent viral replications and infections on the cellular level. Its similar to energetic theory wherein two standing wave patterns cancel eachother out but instead of energetic paradigms, biological ones. You would want it to be designed with a biological half life to cease replication once the virons were encapsulated to ensure no mutation or adverse effects on the body. If you were to design such a cell I would keep it Prokaryotic in nature to hopefully ensure more control and less possibility of mutation. This would be a short term solution that would require booster shots for different versions of the pathogen but it would possible help in the short term. These were a few thoughts that I was having and wanted to share. Stay Safe, Stay Sanitized and Stay Supportive, John Ames Birch @johneames2 From: J Birch <Birch403@outlook.com> Sent: April 13, 2020 1:42 AM To: dujarric@un.org <dujarric@un.org>; justin.trudeau@parl.gc.ca <justin.trudeau@parl.gc.ca>; GlobalOttawa@globalnews.ca <GlobalOttawa@globalnews.ca>; news@skynews.com <news@skynews.com>; tips@GlobalTVBC.com <tips@GlobalTVBC.com>; newsonline@ctv.ca <newsonline@ctv.ca>; contact.nbcnews@nbcuni.com <contact.nbcnews@nbcuni.com>; she@emro.who.int <she@emro.who.int>; eurohealthycities@who.int <eurohealthycities@who.int>; ogawah@wpro.who.int <ogawah@wpro.who.int>; Secretary@HHS.gov <Secretary@HHS.gov>; Info@hc-sc.gc.ca <Info@hc-sc.gc.ca> Subject: Re: Pandemic Vaccine Thoughts Continued (Opinion) Hey Everyone, Further to the below I was reading that the coronavirus is an RNA Polymerase or RNA dependent so it produces negative stranded mRNA. I was wondering if anyone has attempted Antisense therapy to create an Nucleic strand to bind to the mRNA and prevent its ability to replicate in the body. Essentially antisense is the ability to turn off the cell so to speak and halt replication of the virus on the cellular level. This was a thought I was having and wanted to share to see if Antisense therapy might help. Stay Safe, Stay Sanitized and Stay Supportive, John Ames Birch @johneames2 From: J Birch Sent: April 9, 2020 11:30 PM To: dujarric@un.org <dujarric@un.org>; justin.trudeau@parl.gc.ca <justin.trudeau@parl.gc.ca>; GlobalOttawa@globalnews.ca <GlobalOttawa@globalnews.ca>; news@skynews.com <news@skynews.com>; tips@GlobalTVBC.com <tips@GlobalTVBC.com>; newsonline@ctv.ca <newsonline@ctv.ca>; contact.nbcnews@nbcuni.com <contact.nbcnews@nbcuni.com>; she@emro.who.int <she@emro.who.int>; eurohealthycities@who.int <eurohealthycities@who.int>; ogawah@wpro.who.int <ogawah@wpro.who.int>; Secretary@HHS.gov <Secretary@HHS.gov> Subject: Pandemic Vaccine Thoughts Continued (Opinion)

Hello Everyone, I have been brushing up on Cellular biology and viral pathology given the situation and I had a few thoughts I wanted to share. I realize you are some of the smartest people on the planet and might have already reviewed similar ideas but I wanted to see if I can assist in any way possible. I was thinking that since viral transmission occurs within the body through the cell membrane perhaps there is something that we can do to prevent the receptor from allowing the virus entry into the cells or new cells if infection is already present. Similar to locking the cell membrane like a door against this specific pathogen. Perhaps we can introduce a chemical into the body to make the receptors super hydrophobic so to speak coded against allowing the Virus entry into the cell. Additionally I was wondering if there is a way that we can introduce a substance that will prevent DNA or RNA replication on the specific Coronavirus Virons by either absorbing or eliminating the proteins used to create the capsids within the cell. Therefore if cell Lysis occurs then incomplete progeny cells would be released and hopefully be destroyed easier by the body. I was also wondering if we can focus on creating viral proteins that are hostile towards the viral DNA or RNA and when encapsulated destroy the viral DNA or RNA. This way we can halt the replication of both encapsulated or naked viral capsids. Additionally, I was also thinking perhaps we can prevent the unpacking or dissociation process within the Cytoplasm to make the cytoplasm itself hostile to the virus and thereby negate the DNA or RNA replication process. Again, I am not an expert but these were a few thoughts I was having in relation to the Pandemic and I was hoping some of these ideas might help with the necessary work you are doing to save us from this Pathogen. Once again, I appreciate you all and the efforts you are making to help. Stay Safe, Stay Sanitized and Stay Supportive, John Ames Birch @johneames2